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KMID : 0043320050280121386
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1386 ~ p.1391
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The Roles of Kupffer Cells in Hepatic Dysfunction Induced by Ischemia/Reperfusion in Rats
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Jung Joo-Yeon
Lee Sun-Mee
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Abstract
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This study examined the role of Kupffer cells in altering the hepatic secretory and microsomal function during ischemia and reperfusion (ls/Rp). Rats were subjected to 60 min of hepatic ischemia, followed by 1 and 5 h of reperfusion. Gadolinium chloride (, 7.5 mg/kg body weight, intravenously) was used to inactivate the Kupffer cells 1 day prior to ischemia. Is/Rp markedly increased the serum aminotransferase level and the extent of lipid peroxidation. significantly attenuated these increases. Is/Rp markedly decreased the bile. flow and cholate output, and restored their secretion. The cytochrome P450 content was decreased by Is/Rp. However, these decreases were not prevented by . The aminopyrine N-demethylase activity was decreased by Is/Rp, while the aniline p-hydroxylase activity was increased. prevented the increase in the aniline p-hydroxylase activity. Overall, Is/Rp diminishes the hepatic secretory and microsomal drug-metabolizing functions, and Kupffer cells are involved in this hepatobiliary dysfunction.
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KEYWORD
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Ischemia/reperfusion, Hepatic secretion, Drug metabolism, Gadolinium chloride, Kupffer cells
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